Research Groups

Our research groups are the driving force behind pioneering advancements at the intersection of clinical, applied, and basic research. Organized into independent teams of scientists and students, our groups lead cutting-edge research programs while fostering collaboration and interdisciplinary interactions.

Currently, NIMSB hosts two dynamic research groups, with four more set to join in the coming months, strengthening our diverse and innovative research ecosystem. Together, our growing research community is committed to advancing knowledge, inspiring discovery, and translating findings to address critical societal challenges.

Our research groups integrate advanced cell analytics, human microphysiological models, and AI to unravel disease mechanisms and drive solutions that enhance early diagnosis and treatment.

Jacinto Lab about

Jacinto Lab

António Jacinto

SCIENTIFIC DIRECTOR AND PI

Cellular Reprogramming in Regeneration and Cancer​​

Our group’s main interest is to understand regenerative processes to address health challenges with high impact on quality of life.​

​We focus on the roles of cellular metabolism and the tissue microenvironment in regeneration and cancer. We apply systems-biology approaches and experimental methods, including advanced genetics, high-resolution microscopy, and multi-omics analytics, to study retina and fin regeneration in zebrafish, and cancer biology using human organoids. We expect that work across animal models and human in vitro systems will deepen understanding of tissue physiology and disease. Ultimately, we aim to enable better diagnostics and novel therapeutic strategies by enhancing human regenerative capacity.​

Jacinto Lab Projects

Know our projects

MetaRetina

Metabolic driven transcriptional regulation during retina regeneration

Jacinto Lab Team

Meet our team

Raquel Lourenço​

SENIOR INVESTIGATOR

Ana Teresa Tavares​

SENIOR INVESTIGATOR

Daniel Ribeiro​​

RESEARCHER​

Rute Salvador​​

PHD FELLOW

Inês Gomes​

PHD FELLOW

Ana Patrícia Silva​​

PHD FELLOW

Rita Pereira​​

MSC FELLOW

Jacinto Lab Publications

  • Porfírio-Rodrigues P; Pereira T; Jacinto A; Lara Carvalho. “Dachsous is a key player in epithelial wound closure through modulating cell shape changes and tissue mechanics.”. Journal of cell science (2025): https://doi.org/10.1242/jcs.263674. 10.1242/jcs.263674

  • Ana S Brandão; Jorge Borbinha; Telmo Pereira; Patrícia H Brito; Raquel Lourenço; Anabela Bensimon-Brito; Antonio Jacinto. “A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration“. eLife 11 (2022): https://doi.org/10.7554/eLife.76987. 10.7554/eLife.7698787

  • Diana P Saraiva; Bruna F Correia; Rute Salvador; Nídia de Sousa; Antonio Jacinto; Sofia Braga; MG Cabral. “Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses”. Oncotarget 12 24 (2021): 2388-2403. https://novaresearch.unl.pt/en/publications/a7293e16-0241-4147-93a2-95d23181aba6. 10.18632/oncotarget.28135

  • Diogo Paramos-de-Carvalho; Isaura Martins; Ana Margarida Cristóvão; Ana Filipa Dias; Dalila Neves-Silva; Telmo Pereira; Diana Chapela; et al. “Targeting senescent cells improves functional recovery after spinal cord injury“. Cell Reports 36 1 (2021): https://novaresearch.unl.pt/en/publications/c79d5633-f09f-42ac-9dab-252d10341380. 10.1016/j.celrep.2021.109334

  • Lara Carvalho; Pedro Patricio; Susana Ponte; Carl-Philipp Heisenberg; Luis Almeida; André S. Nunes; Nuno A.M. Araújo; Antonio Jacinto. “Occluding junctions as novel regulators of tissue mechanics during wound repair“. The Journal of Cell Biology (2018): jcb.201804048-jcb.201804048. https://doi.org/10.1083/jcb.201804048. 10.1083/jcb.201804048

Nunes dos Santos Lab about

Cláudia Nunes dos Santos

Vice-director for Research and PI

Our goal is to understand the mechanisms of cellular processes related to nutrition at a molecular level, in the context of chronic diseases associated with lifestyle.

We have a particular interest in studying the metabolism of polyphenols in humans and animal models using metabolomic approaches, including bioaccessibility, bioavailability, brain permeability, and cellular metabolism, as well as the bioactivity of polyphenol metabolites in models of neurodegenerative diseases. Our focus is on Parkinson’s disease, neurodegeneration, neuroinflammation, and the permeability of the blood-brain barrier.

We conduct mechanistic studies using disease-relevant models, such as yeast models, cellular models, and animal models, combined with state-of-the-art cellular and molecular approaches to uncover the molecular mechanisms of cytoprotection mediated by polyphenol-derived metabolites.

Nunes dos Santos Lab Projects

Know our projects

LIMBo

Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation.

NEUROSHIELD

Novel small molecule attenuator of neuroinflammation in Parkinson’s Disease.

DeCYPher

Innovating Bioprocesses with Microbes and AI

NEXUS

Unlocking the Neuroimmune Crosstalk in Neurodegenerative Diseases: The Impact  of Polyphenol Metabolites on Immune Cells Brain Infiltration

MISSION

A novel microphysiological system of Parkinson’s disease integrating dopaminergic loss and neuroinflammation crosstalk 

Nunes dos Santos Lab Team

Meet the team

Inês Figueira

SENIOR RESEARCHER

Diogo Carregosa

JUNIOR RESEARCHER

Jorge Silva

JUNIOR RESEARCHER

Ana Rita Garcia

PHD FELLOW

Daniela Marques

PHD FELLOW

Catarina Pinto

PHD FELLOW

Carlos Pita

PHD FELLOW

Inês Silva

PHD FELLOW

Diogo Louro

PHD FELLOW

Inês Paiva

SHARED PHD FELLOW

Liza Hilman

PHD FELLOW

Marco Zadra

PHD FELLOW

Daniela Parente

MSC STUDENT

Nunes dos Santos Lab Publications

  • Diogo Carregosa; Natasa Loncarevic-Vasiljkovic; Raquel Feliciano; Diogo Moura-Louro; César S. Mendes; Claudia Nunes dos Santos. “Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain”. Journal of Inflammation (United Kingdom) 21 1 (2024): https://novaresearch.unl.pt/en/publications/80981cc5-624f-47de-bfe7-570f5732f568.10.1186/s12950-024-00412-y

  • Daniela Marques; Diogo Moura-Louro; Inês P. Silva; Sara Matos; Cláudia Nunes dos Santos; Inês Figueira. “Unlocking the potential of low-molecular-weight (Poly)phenol metabolites: Protectors at the blood-brain barrier frontier”. Neurochemistry International (2024): http://dx.doi.org/10.1016/j.neuint.2024.105836.10.1016/j.neuint.2024.105836

  • Rafael Carecho; Daniela Marques; Diogo Carregosa; Domenico Masuero; Mar Garcia-Aloy; Federica Tramer; Sabina Passamonti; et al. “Circulating low-molecular-weight (poly)phenol metabolites in the brain”. Food and Function 15 15 (2024): 7812-7827. https://novaresearch.unl.pt/en/publications/f9ad78a9-bc61-430c-a672-da0e390a4c83.10.1039/d4fo01396d

  • Catarina J.G. Pinto; María Ángeles Ávila-Gálvez; Yilong Lian; Pedro Moura-Alves; Cláudia Nunes dos Santos. “Targeting the aryl hydrocarbon receptor by gut phenolic metabolites: A strategy towards gut inflammation”. Redox Biology (2023): https://doi.org/10.1016/j.redox.2023.102622.10.1016/j.redox.2023.102622

  • Rita Rosado-Ramos; Gonçalo Manuel Poças; Daniela Marques; Alexandre Foito; David M Sevillano; Mafalda Lopes-da-Silva; Luis G Goncalves; et al. “Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage”. Nature Communications 14 1 (2023): 1918-1918. https://novaresearch.unl.pt/en/publications/49c31a60-a665-4b18-bca4-8b339744208f.10.1038/s41467-023-37561-2